Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.
Int J Pharm Pract
; 32(3): 259-264, 2024 May 07.
Article
in En
| MEDLINE
| ID: mdl-38438314
ABSTRACT
OBJECTIVES:
To determine risks associated with uricosurics in COVID-19 patients.METHODS:
A systematic review and meta-analysis was conducted by systematically searching electronic databases. KEYFINDINGS:
The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.94-1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI 0.65-0.94).CONCLUSIONS:
The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ascorbic Acid
/
Uric Acid
/
Randomized Controlled Trials as Topic
/
COVID-19
Limits:
Humans
Language:
En
Journal:
Int J Pharm Pract
Journal subject:
FARMACIA
Year:
2024
Document type:
Article
Affiliation country: