Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas.
Beilstein J Org Chem
; 20: 460-469, 2024.
Article
in En
| MEDLINE
| ID: mdl-38440170
ABSTRACT
Solutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride ion that facilitates limiting enolization processes, and an electrophilic N-F fluorinating agent that is reactive towards neutral enol species.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Beilstein J Org Chem
Year:
2024
Document type:
Article
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