Acoustic Activation Imaging With Intravenous Perfluoropropane Nanodroplets Results in Selective Bioactivation of the Risk Area.
J Ultrasound Med
; 43(6): 1063-1080, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38440926
ABSTRACT
BACKGROUND:
Acoustically activatable perfluoropropane droplets (PD) can be formulated from commercially available microbubble preparations. Diagnostic transthoracic ultrasound frequencies have resulted in acoustic activation (AA) predominately within myocardial infarct zones (IZ).OBJECTIVE:
We hypothesized that the AA area following acute coronary ischemia/reperfusion (I/R) would selectively enhance the developing scar zone, and target bioeffects specifically to this region.METHODS:
We administered intravenous PD in 36 rats and 20 pigs at various stages of myocardial scar formation (30 minutes, 1 day, and 7 days post I/R) to determine what effect infarct age had on the AA within the IZ. This was correlated with histology, myeloperoxidase activity, and tissue nitrite activity.RESULTS:
The degree of AA within the IZ in rats was not associated with collagen content, neutrophil infiltration, or infarct age. AA within 24 hours of I/R was associated with increased nitric oxide utilization selectively within the IZ (P < .05 compared with remote zone). The spatial extent of AA in pigs correlated with infarct size only when performed before sacrifice at 7 days (r = .74, P < .01).CONCLUSIONS:
Acoustic activation of intravenous PD enhances the developing scar zone following I/R, and results in selective tissue nitric oxide utilization.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fluorocarbons
/
Myocardial Infarction
Limits:
Animals
Language:
En
Journal:
J Ultrasound Med
Year:
2024
Document type:
Article
Affiliation country: