Exploring the antimicrobial and cytotoxic potential of novel chloroquine analogues.
Future Med Chem
; 16(8): 737-749, 2024.
Article
in En
| MEDLINE
| ID: mdl-38456272
ABSTRACT
Aim:
To synthesize novel chloroquine analogues and evaluate them for antimicrobial and cytotoxic potential.Methods:
Novel analogues were synthesized from chloroquine by nucleophilic substitution reaction at the 4-amino position.Results:
Analogue CS1 showed maximum antimicrobial potential (30.3 ± 0.15 mm zone) against Pseudomonas aeruginosa and produced a 19.2 ± 0.21 mm zone against Candida albicans, while CS0 produced no zone at the same concentration. Analogue CS9 has excellent cytotoxic potential (HeLa cell line), showing 100% inhibition (IC50 = 8.9 ± 1.2 µg/ml), compared with CS0 (61.9% inhibition at 30 µg/ml).Conclusion:
These synthesized chloroquine analogues have excellent activity against different microbial strains and cervical cancer cell lines (HeLa) compared with their parent molecule.
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Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas aeruginosa
/
Candida albicans
/
Microbial Sensitivity Tests
/
Chloroquine
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Future Med Chem
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: