Advances in Skin-on-a-Chip Technologies for Dermatological Disease Modeling.
J Invest Dermatol
; 144(8): 1707-1715, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38493383
ABSTRACT
Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models. In this paper, we review current SoC technologies, highlighting their potential as an alternative to animal models for a deeper understanding of complex skin conditions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Diseases
/
Lab-On-A-Chip Devices
Limits:
Animals
/
Humans
Language:
En
Journal:
J Invest Dermatol
/
J. invest. dermatol
/
Journal of investigative dermatology
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: