Organocatalytic enantioselective decarboxylative protonation of α-alkyl-α-aryl malonate monoesters.
Chem Commun (Camb)
; 60(28): 3854-3857, 2024 Apr 02.
Article
in En
| MEDLINE
| ID: mdl-38497353
ABSTRACT
In contrast to the well-established enzymatic enantioselective decarboxylative protonation (EDP), the corresponding chemocatalytic reactions of acyclic malonic acid derivatives remain challenging. Herein, we developed a biomimetic EDP of α-alkyl-α-aryl malonate monoesters using a chiral 1,2-trans-diaminocyclohexane-based N-sulfonamide as an organocatalyst. The method demonstrates excellent chemical yields, good enantioselectivity, mild reaction conditions, and the generation of only CO2 as waste.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2024
Document type:
Article
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