Impact of smoking reduction on lung cancer risk in patients with COPD who smoked fewer than 30 pack-years: a nationwide population-based cohort study.
Respir Res
; 25(1): 133, 2024 Mar 18.
Article
in En
| MEDLINE
| ID: mdl-38500143
ABSTRACT
BACKGROUND:
The effects of smoking reduction on the incidence of lung cancer in patients with chronic obstructive pulmonary disease (COPD) are not well known. This study aimed to investigate the effects of changes in smoking habits after COPD diagnosis on lung cancer development in patients who smoked less than 30 pack-years.METHODS:
This nationwide retrospective cohort study included 16,832 patients with COPD who smoked less than 30 pack-years at the time of COPD diagnosis. Based on changes in smoking habits in the health screening examination data, smokers were categorized into three groups quitters, reducers, and sustainers. The primary outcome was the risk of lung cancer development, which was estimated using the Cox proportional hazards model. We also modelled the amount of smoking reduction as a continuous variable.RESULTS:
During a median follow-up of 4 years, the cumulative incidence of lung cancer was the highest among sustainers, followed by reducers and quitters. Compared with sustainers, reducers (adjusted HR 0.74, 95% CI0.56-0.98) and quitters (adjusted HR 0.78, 95% CI0.64-0.96) had a significantly lower risk of lung cancer. Incidence of lung cancer showed a decreasing trend with a decreasing amount of smoking (P for linearity < 0.01).CONCLUSIONS:
In patients with COPD who smoked less than 30 pack-years, smoking reduction and cessation lowered the risk of lung cancer.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pulmonary Disease, Chronic Obstructive
/
Smoking Reduction
/
Lung Neoplasms
Limits:
Humans
Language:
En
Journal:
Respir Res
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: