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Surgical Resection of Primary Tumor for Bone Metastatic Breast Cancer Patients at Initial Presentation.
Kitsuya, Nayu; Matsuoka, Masatake; Onodera, Tomohiro; Yokota, Isao; Iwasaki, Koji; Suzuki, Yuki; Hamasaki, Masanari; Kondo, Eiji; Iwasaki, Norimasa.
Affiliation
  • Kitsuya N; Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
  • Matsuoka M; Department of Orthopaedic Surgery, Hakodate Central General Hospital, Hakodate, Japan.
  • Onodera T; Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan; masatakem@pop.med.hokudai.ac.jp.
  • Yokota I; Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
  • Iwasaki K; Department of Biostatistics, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
  • Suzuki Y; Department of Functional Reconstruction for the Knee Joint, Hokkaido University, Sapporo, Japan.
  • Hamasaki M; Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
  • Kondo E; Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
  • Iwasaki N; Centre for Sports Medicine, Hokkaido University Hospital, Sapporo, Japan.
Anticancer Res ; 44(4): 1591-1601, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38537990
ABSTRACT
BACKGROUND/

AIM:

The purpose of this study was to investigate whether primary tumor resection in patients with bone metastatic breast cancer has an impact on survival using the Surveillance, Epidemiology, and End Results database, considering subtype classification. PATIENTS AND

METHODS:

We included all female patients with bone metastatic breast cancer at initial presentation between 2010 and 2016 with known hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) statuses. Cases showing unknown cause of death or unknown HR/HER2 status were excluded. Survival analysis was performed using Cox proportional hazards modeling to calculate hazard ratios (HZR).

RESULTS:

Of the 13,450 patients included in this study, 2,073 patients were HR+/HER2+, 8,597 patients were HR+/HER2-, 797 patients were HR-/HER2+, and 1,182 patients were HR-/HER2- (triple-negative). Five-year overall survival (OS) rate was 34.5% in HR+/HER2+, 26.0% in HR+/HER2-, 29.2% in HR-/HER2+ and 8.0% in triple-negative. Triple-negative patients showed the worsen OS [HR+/HER2+ HZR=2.1, 95% confidence interval (CI)=1.9-2.3; HR+/HER2- HZR= 2.4, 95%CI=2.2-2.6; HR-/HER2+ HZR=1.5, 95%CI=1.3-1.6]. After excluding patients who died within six months, primary tumor resection prolonged survival in each subtype classification except HR-/HER2+.

CONCLUSION:

Patients with triple-negative bone metastatic breast cancer showed unfavorable survival. Primary tumor resection prolonged survival in each subtype except for HR-/HER2+.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / Breast Neoplasms Limits: Female / Humans Language: En Journal: Anticancer Res Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / Breast Neoplasms Limits: Female / Humans Language: En Journal: Anticancer Res Year: 2024 Document type: Article Affiliation country: Country of publication: