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Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms.
Agostini, Antonio; Piro, Geny; Inzani, Frediano; Quero, Giuseppe; Esposito, Annachiara; Caggiano, Alessia; Priori, Lorenzo; Larghi, Alberto; Alfieri, Sergio; Casolino, Raffaella; Scaglione, Giulia; Tondolo, Vincenzo; Cammarota, Giovanni; Ianiro, Gianluca; Corbo, Vincenzo; Biankin, Andrew V; Tortora, Giampaolo; Carbone, Carmine.
Affiliation
  • Agostini A; Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Piro G; Medical Oncology, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy.
  • Inzani F; Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. geny.piro@policlinicogemelli.it.
  • Quero G; Medical Oncology, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy. geny.piro@policlinicogemelli.it.
  • Esposito A; Department of Anatomic Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Caggiano A; Pancreatic Surgery Unit, Gemelli Pancreatic Advanced Research Center (CRMPG), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Priori L; Digestive Surgery Unit, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy.
  • Larghi A; Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Alfieri S; Medical Oncology, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy.
  • Casolino R; Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Scaglione G; Medical Oncology, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy.
  • Tondolo V; Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Cammarota G; Medical Oncology, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy.
  • Ianiro G; Digestive Endoscopy Unit, Fondazione Policlinico A. Gemelli IRCCS and Center for Endoscopic Research, Therapeutics and Training, Catholic University, Rome, Italy.
  • Corbo V; Pancreatic Surgery Unit, Gemelli Pancreatic Advanced Research Center (CRMPG), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Biankin AV; Digestive Surgery Unit, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy.
  • Tortora G; Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
  • Carbone C; Department of Anatomic Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Nat Commun ; 15(1): 2764, 2024 Mar 29.
Article in En | MEDLINE | ID: mdl-38553466
ABSTRACT
The existing Intraductal Papillary Mucinous Neoplasm (IPMN) risk stratification relies on clinical and histological factors, resulting in inaccuracies and leading to suboptimal treatment. This is due to the lack of appropriate molecular markers that can guide patients toward the best therapeutic options. Here, we assess and confirm subtype-specific markers for IPMN across two independent cohorts of patients using two Spatial Transcriptomics (ST) technologies. Specifically, we identify HOXB3 and ZNF117 as markers for Low-Grade Dysplasia, SPDEF and gastric neck cell markers in borderline cases, and NKX6-2 and gastric isthmus cell markers in High-Grade-Dysplasia Gastric IPMN, highlighting the role of TNFα and MYC activation in IPMN progression and the role of NKX6-2 in the specific Gastric IPMN progression. In conclusion, our work provides a step forward in understanding the gene expression landscapes of IPMN and the critical transcriptional networks related to PDAC progression.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Adenocarcinoma, Mucinous / Carcinoma, Pancreatic Ductal / Pancreatic Intraductal Neoplasms Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Adenocarcinoma, Mucinous / Carcinoma, Pancreatic Ductal / Pancreatic Intraductal Neoplasms Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: