Dysregulated bidirectional epithelial-mesenchymal crosstalk: a core determinant of lung fibrosis progression.
Chin Med J Pulm Crit Care Med
; 2(1): 27-33, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38558961
ABSTRACT
Progressive lung fibrosis is characterised by dysregulated extracellular matrix (ECM) homeostasis. Understanding of disease pathogenesis remains limited and has prevented the development of effective treatments. While an abnormal wound healing response is strongly implicated in lung fibrosis initiation, factors that determine why fibrosis progresses rather than regular tissue repair occurs are not fully explained. Within human lung fibrosis there is evidence of altered epithelial and mesenchymal lung populations as well as cells undergoing epithelial-mesenchymal transition (EMT), a dynamic and reversible biological process by which epithelial cells lose their cell polarity and down-regulate cadherin-mediated cell-cell adhesion to gain migratory properties. This review will focus upon the role of EMT and dysregulated epithelial-mesenchymal crosstalk in progressive lung fibrosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chin Med J Pulm Crit Care Med
Year:
2024
Document type:
Article
Affiliation country: