Your browser doesn't support javascript.
loading
Catechol-O-methyltransferase and monoamine oxidase B inhibitory activities of Australian bee pollen.
Watanabe, Chie; Yanagihara, Aoi; Miyata, Ryo; Mitsui, Taichi; Honda, Chihiro; Fujinami, Daisuke; Kumazawa, Shigenori.
Affiliation
  • Watanabe C; Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.
  • Yanagihara A; Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.
  • Miyata R; Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.
  • Mitsui T; Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa, Japan.
  • Honda C; Nagaragawa Research Center, API Co., Ltd., Gifu, Japan.
  • Fujinami D; Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.
  • Kumazawa S; Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.
Biosci Biotechnol Biochem ; 88(6): 665-670, 2024 May 22.
Article in En | MEDLINE | ID: mdl-38561637
ABSTRACT
Bee pollen is an apicultural product collected by honeybees from flower stamens and used as a functional food worldwide. In the present study, we aim to elucidate the functions of Australian bee pollen. Australian bee pollen extracts and their main components were tested for catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) inhibitory activities. These enzymes are key neurotransmitters involved in Parkinson's disease and depression. Myricetin (5), tricetin (6), and luteolin (7) exhibited high COMT inhibitory activities (half maximal inhibitory concentration [IC50] = 23.3, 13.8, and 47.4 µM, respectively). In contrast, 5, 7, and annulatin (8) exhibited MAOB inhibitory activities (IC50 = 89.7, 32.8, and 153 µM, respectively). Quantitative analysis via high-performance liquid chromatography revealed that 5 was abundant in Australian bee pollen extracts. Our findings suggest that 5 contributes to the COMT and MAOB inhibitory activities of Australian bee pollen.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pollen / Catechol O-Methyltransferase Inhibitors / Monoamine Oxidase Inhibitors Limits: Animals Country/Region as subject: Oceania Language: En Journal: Biosci Biotechnol Biochem Journal subject: BIOQUIMICA / BIOTECNOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pollen / Catechol O-Methyltransferase Inhibitors / Monoamine Oxidase Inhibitors Limits: Animals Country/Region as subject: Oceania Language: En Journal: Biosci Biotechnol Biochem Journal subject: BIOQUIMICA / BIOTECNOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: