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Diminished neutralizing activity against the XBB1.5 strain in 55.9% of individuals post 6 months COVID-19 mRNA booster vaccination: insights from a pseudovirus assay on 1,353 participants in the Fukushima vaccination community survey, Japan.
Zhao, Tianchen; Tani, Yuta; Makino-Okamura, Chieko; Takita, Morihito; Yamamoto, Chika; Kawahara, Eiki; Abe, Toshiki; Sugiura, Sota; Yoshimura, Hiroki; Uchiyama, Taiga; Yamazaki, Isato; Ishigame, Harumichi; Ueno, Takaharu; Okuma, Kazu; Wakui, Masatoshi; Fukuyama, Hidehiro; Tsubokura, Masaharu.
Affiliation
  • Zhao T; General Incorporated Association for Comprehensive Disaster Health Management Research Institute, Tokyo, Japan.
  • Tani Y; Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
  • Makino-Okamura C; General Incorporated Association for Comprehensive Disaster Health Management Research Institute, Tokyo, Japan.
  • Takita M; Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan.
  • Yamamoto C; Division of Immunology, Near-InfraRed Photo-Immunotherapy Research Institute, Kansai Medical University, Hirakata, Osaka, Japan.
  • Kawahara E; Infectious Diseases Research Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
  • Abe T; General Incorporated Association for Comprehensive Disaster Health Management Research Institute, Tokyo, Japan.
  • Sugiura S; Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
  • Yoshimura H; General Incorporated Association for Comprehensive Disaster Health Management Research Institute, Tokyo, Japan.
  • Uchiyama T; Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
  • Yamazaki I; Division of Immunology, Near-InfraRed Photo-Immunotherapy Research Institute, Kansai Medical University, Hirakata, Osaka, Japan.
  • Ishigame H; Infectious Diseases Research Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
  • Ueno T; Cell Integrative Science Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Kanagawa, Japan.
  • Okuma K; Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
  • Wakui M; General Incorporated Association for Comprehensive Disaster Health Management Research Institute, Tokyo, Japan.
  • Fukuyama H; General Incorporated Association for Comprehensive Disaster Health Management Research Institute, Tokyo, Japan.
  • Tsubokura M; Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.
Front Immunol ; 15: 1337520, 2024.
Article in En | MEDLINE | ID: mdl-38562937
ABSTRACT
This study investigates the neutralizing activity against the XBB1.5 variant and the ancestral strain in a population post-bivalent vaccination using a pseudo virus assay validated with authentic virus assay. While bivalent booster vaccination and past infections enhanced neutralization against the XBB 1.5 strain, individuals with comorbidities showed reduced responses. The study suggests the need for continuous vaccine updates to address emerging SARS-CoV-2 variants and highlights the importance of monitoring real-world immune responses.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Country/Region as subject: Asia Language: En Journal: Front Immunol Year: 2024 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Country/Region as subject: Asia Language: En Journal: Front Immunol Year: 2024 Document type: Article Affiliation country: Country of publication: