Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth.
Cell Death Discov
; 10(1): 161, 2024 Apr 02.
Article
in En
| MEDLINE
| ID: mdl-38565596
ABSTRACT
Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1 induced both necrotic and apoptotic cell death specifically in cancer cells while showing minimal toxicity in non-cancerous cells. Mechanistically, CKS1 disrupted the cell membrane of cancer cells quickly after treatment and activated the apoptotic pathway at later time points. Furthermore, immunogenic molecules were released from CKS1-treated cells, indicating that CKS1 induces immunogenic cell death. CKS1 effectively suppressed tumor growth in vivo. Collectively, these data demonstrate that CKS1 functions as an oncolytic peptide and has a therapeutic potential to treat cancer.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Cell Death Discov
Year:
2024
Document type:
Article
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