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Tyrosine nitration enhances the allergenic potential of house dust mite allergen Der p 2.
Li, Zhiqi; Tian, Jingyi; Yang, Fangxing.
Affiliation
  • Li Z; Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, 310058, Hangzhou, China.
  • Tian J; Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, 310058, Hangzhou, China.
  • Yang F; Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, 310058, Hangzhou, China; Innovation Center of Yangtze River Delta, Zhejiang University, 314100, Jiashan, China. Electronic address: fxyang@zju.edu.cn.
Environ Res ; 252(Pt 1): 118826, 2024 Jul 01.
Article in En | MEDLINE | ID: mdl-38579999
ABSTRACT
Nitration of allergenic proteins caused by atmospheric pollutants O3 and NO2 may enhance their allergenic potential. In the study, the influence of nitration was investigated on the allergenicity of Der p 2, which is a main allergen from house dust mites and plays an important role in allergenic rhinitis and asthma. The results reveal that nitrated Der p 2 enhanced the IgE-binding capacity, upregulated the mRNA expression and release of IL-6 and IL-8 from bronchial epithelial cells, and induced higher levels of specific-IgE, TH2 cytokines and white blood cells in mice. Besides, nitrated Der p 2 caused more severe oxidative stress and allergenic symptoms in mice. It is concluded that nitration enhanced the allergenicity of Der p 2 through not only directly inducing higher amount of specific-IgE and stronger responses of TH2 cytokines, but also indirectly aggravating allergic symptoms by oxidative stress and adjuvant-like activation airway epithelial cells. The study suggests that the contribution of nitration to the promotion in allergenicity should not be ignored when precisely assessing the risk of house dust mite allergens in real environment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antigens, Dermatophagoides / Arthropod Proteins Limits: Animals / Female / Humans Language: En Journal: Environ Res Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antigens, Dermatophagoides / Arthropod Proteins Limits: Animals / Female / Humans Language: En Journal: Environ Res Year: 2024 Document type: Article Affiliation country: Country of publication: