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Exosome-loaded decellularized tissue: Opening a new window for regenerative medicine.
Rahmati, Shima; Khazaei, Mozafar; Abpeikar, Zahra; Soleimanizadeh, Arghavan; Rezakhani, Leila.
Affiliation
  • Rahmati S; Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  • Khazaei M; Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Abpeikar Z; Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
  • Soleimanizadeh A; Faculty of Medicine, Graduate School 'Molecular Medicine, University of Ulm, 89081, Ulm, Germany.
  • Rezakhani L; Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: leila_rezakhani@yahoo.com.
J Tissue Viability ; 33(2): 332-344, 2024 May.
Article in En | MEDLINE | ID: mdl-38594147
ABSTRACT
Mesenchymal stem cell-derived exosomes (MSCs-EXO) have received a lot of interest recently as a potential therapeutic tool in regenerative medicine. Extracellular vesicles (EVs) known as exosomes (EXOs) are crucial for cell-cell communication throughout a variety of activities including stress response, aging, angiogenesis, and cell differentiation. Exploration of the potential use of EXOs as essential therapeutic effectors of MSCs to encourage tissue regeneration was motivated by success in the field of regenerative medicine. EXOs have been administered to target tissues using a variety of methods, including direct, intravenous, intraperitoneal injection, oral delivery, and hydrogel-based encapsulation, in various disease models. Despite the significant advances in EXO therapy, various methods are still being researched to optimize the therapeutic applications of these nanoparticles, and it is not completely clear which approach to EXO administration will have the greatest effects. Here, we will review emerging developments in the applications of EXOs loaded into decellularized tissues as therapeutic agents for use in regenerative medicine in various tissues.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Regenerative Medicine / Exosomes Limits: Animals / Humans Language: En Journal: J Tissue Viability Journal subject: ENFERMAGEM / FISIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Regenerative Medicine / Exosomes Limits: Animals / Humans Language: En Journal: J Tissue Viability Journal subject: ENFERMAGEM / FISIOLOGIA Year: 2024 Document type: Article Affiliation country: Country of publication: