Fourteen undescribed steroidal saponins from Solanum capsicoides leaves and their neuroprotective effects.
Phytochemistry
; 222: 114091, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38615926
ABSTRACT
A total of 14 previously undescribed steroidal saponins named capsicsaponins A-N were isolated from the leaves of Solanum capsicoides, encompassing various types, including cholesterol derivatives and pseudospirostanol saponins. The structures of all compounds were determined through comprehensive analysis of spectroscopic data (1D NMR and 2D NMR), along with physicochemical analysis methods (acid hydrolysis, OR, and UV). Moreover, in the H2O2-induced pheochromocytoma cell line model, compounds 1-14 were screened for their neuroprotective effects on cells. The bioassay results demonstrated compounds 8-14 were able to revive cell viability compared to the positive control edaravone. The damage neuroprotection of the most active compound was further explored.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saponins
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Cell Survival
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Plant Leaves
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Neuroprotective Agents
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Solanum
Limits:
Animals
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: