Lipoic acid attachment to proteins: stimulating new developments.
Microbiol Mol Biol Rev
; 88(2): e0000524, 2024 Jun 27.
Article
in En
| MEDLINE
| ID: mdl-38624243
ABSTRACT
SUMMARYLipoic acid-modified proteins are essential for central metabolism and pathogenesis. In recent years, the Escherichia coli and Bacillus subtilis lipoyl assembly pathways have been modified and extended to archaea and diverse eukaryotes including humans. These extensions include a new pathway to insert the key sulfur atoms of lipoate, several new pathways of lipoate salvage, and a novel use of lipoic acid in sulfur-oxidizing bacteria. Other advances are the modification of E. coli LplA for studies of protein localization and protein-protein interactions in cell biology and in enzymatic removal of lipoate from lipoyl proteins. Finally, scenarios have been put forth for the evolution of lipoate assembly in archaea.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacillus subtilis
/
Thioctic Acid
/
Escherichia coli
Limits:
Humans
Language:
En
Journal:
Microbiol Mol Biol Rev
Journal subject:
BIOLOGIA MOLECULAR
/
MICROBIOLOGIA
Year:
2024
Document type:
Article
Affiliation country: