P16 and HPV status in head and neck sarcomas and sarcomatoid carcinomas.
Ann Diagn Pathol
; 71: 152307, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38626591
ABSTRACT
Human papillomavirus (HPV)-positive oropharyngeal carcinoma is a distinct type of head and neck carcinoma with improved prognosis. p16 immunostaining is often used as a surrogate marker for HPV infection in this particular setting. The aim of this study is to estimate the prevalence of p16 staining and HPV infection in head and neck sarcomatoid carcinomas as well as head and neck sarcomas. 21 sarcomatoid carcinomas and 28 head and neck sarcomas were tested for p16 positivity using immunohistochemical staining, and for high-risk HPV infection using In situ hybridization (ISH). 24 % of sarcomatoid carcinomas and 21 % of sarcomas were positive for p16 staining. All 49 cases were negative for HPV ISH. The results confirm that p16 staining is not specific and may not be associated with HPV infection in non-oropharyngeal head and neck sites. They also indicate that non-oropharyngeal head and neck sarcomatoid carcinomas are not likely to be HPV related.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcoma
/
In Situ Hybridization
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Cyclin-Dependent Kinase Inhibitor p16
/
Papillomavirus Infections
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Head and Neck Neoplasms
Limits:
Adult
/
Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Ann Diagn Pathol
/
Ann. diagn. pathol
/
Annals of diagnostic pathology
Journal subject:
PATOLOGIA
Year:
2024
Document type:
Article
Country of publication: