Meta-analysis of SATB2 immunohistochemical expression in colorectal cancer versus primary ovarian mucinous neoplasms.
Ann Diagn Pathol
; 71: 152302, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38642469
ABSTRACT
BACKGROUND:
Reliably distinguishing primary ovarian mucinous neoplasms (POMNs) from metastatic colorectal cancers (CRCs) is both challenging to the histopathologist and of great clinical importance. Special AT-rich sequence binding protein-2 (SATB2) has emerged as a useful diagnostic immunohistochemical marker of colorectal cancer. This meta-analysis compares SATB2 expression in POMNs and CRC.METHODS:
A systematic literature search for relevant studies was conducted. Meta-analysis of SATB2 positivity was undertaken using a random effects model.RESULTS:
Seven studies including 711 CRCs and 528 POMNs were included. SATB2 positivity was seen in 81 % (95 % CI 72-88 %) of CRCs and 4 % (95 % CI 1-11 %) of POMNs. Variation was seen in immunohistochemical methods used for SATB2 detection and threshold for positivity.CONCLUSION:
SATB2 staining remains high in CRC and low in POMNs, supporting its use in differentiating these two pathologies with vastly differing prognosis and treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Transcription Factors
/
Immunohistochemistry
/
Colorectal Neoplasms
/
Biomarkers, Tumor
/
Adenocarcinoma, Mucinous
/
Matrix Attachment Region Binding Proteins
Limits:
Female
/
Humans
Language:
En
Journal:
Ann Diagn Pathol
Journal subject:
PATOLOGIA
Year:
2024
Document type:
Article
Affiliation country: