The role of genetic risk factors, diet, and gut microbiota in type 1 diabetes mellitus, pancreas and pancreatic islet transplantation.
Endokrynol Pol
; 75(2): 140-147, 2024.
Article
in En
| MEDLINE
| ID: mdl-38646984
ABSTRACT
Despite advances in insulin delivery and glucose monitoring technology, prevention of the progression of secondary complications in patients with type 1 diabetes (T1DM) remains a challenge. Beta cell replacement therapy in the form of islet or pancreas transplantation can restore long-term normoglycaemia with sustained periods of insulin independence among T1DM patients. However, the same genetic, behavioural, or gut microbiota-related factors that promoted autoimmunity and primary islet destruction may also affect the function of transplanted islets and the ultimate results of transplant procedures. In such cases, identifying genetic risk factors and modifying behavioural factors and those related to gut microbiota may be beneficial for the outcomes of transplant procedures. Herein, we review related literature to the identified current gap in knowledge to be addressed in future clinical trials.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Islets of Langerhans Transplantation
/
Diabetes Mellitus, Type 1
/
Gastrointestinal Microbiome
Limits:
Humans
Language:
En
Journal:
Endokrynol Pol
/
Endokrynol. pol
/
Endokrynologia polska
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: