Amniotic Membrane Augmentation for Enucleation After Chemotherapy in Retinoblastoma.
J Pediatr Ophthalmol Strabismus
; 61(4): 291-295, 2024.
Article
in En
| MEDLINE
| ID: mdl-38661308
ABSTRACT
PURPOSE:
To describe amniotic membrane augmentation for enucleation after chemotherapy in retinoblastoma.METHODS:
This was a retrospective study of patients with retinoblastoma who underwent enucleation. The study also evaluated the utility of amniotic membrane grafting in enucleation after chemotherapy in eyes with retinoblastoma.RESULTS:
In this study, 110 eyes of 107 patients were analyzed, and 49 patients had previous systemic chemotherapy, 13 eyes had previous intra-arterial chemotherapy, and 7 eyes had external beam radiation. Amniotic graft was used in 8 eyes (5 following IAC, 2 following systemic chemotherapy, and 1 after both). After IAC, 3 of 7 eyes without amniotic graft had implant exposure compared to 0 of 6 eyes with amniotic graft (P = .05). Pathological examination of the conjunctiva after intra-arterial chemotherapy showed goblet cell hypoplasia that hinders wound healing.CONCLUSIONS:
Amniotic membrane augmentation improves wound integrity in patients with retinoblastoma, especially following intra-arterial chemotherapy. [J Pediatr Ophthalmol Strabismus. 2024;61(4)291-295.].
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retinoblastoma
/
Eye Enucleation
/
Retinal Neoplasms
/
Amnion
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
J Pediatr Ophthalmol Strabismus
Year:
2024
Document type:
Article
Country of publication: