Screening Mammography for Males With Elevated Breast Cancer Risk, Mutation Carriers, and Gynecomastia.
Clin Breast Cancer
; 24(6): e503-e508, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38670861
ABSTRACT
INTRODUCTION:
The recommendations for annual mammography for male carriers with gynecomastia are controversial. This study investigated the potential link between gynecomastia and breast cancer in male carriers. PATIENTS ANDMETHODS:
The database of a tertiary medical center was retrospectively searched for all male patients who underwent at least 1 digital mammography study from 2016 to 2023. Known carriers of a pathogenic variant in a high-risk breast-cancer gene were identified. Patients were stratified by carrier status, diagnosis of breast cancer, and diagnosis of gynecomastia. Data on demographics, hormone profile, and pathology results were compared.RESULTS:
The cohort included 446 men of whom 82 were known carriers. Gynecomastia was diagnosed by mammography in 251 patients 239/364 noncarriers (66%) and 12/82 carriers (15%) (P < .0001). Breast cancer was found in 21/364 noncarriers (6%) and 6/82 carriers (7%) (P < .6), and in 10/251 patients with gynecomastia (4%) and 17/193 (9%) without gynecomastia (P < .05). Among patients without gynecomastia, the number of breast cancer cases was similar in carriers and noncarriers (P = .3). Among patients with gynecomastia, the rate of breast cancer was higher in carriers (P < .08). On logistic regression analysis, the effect of gynecomastia on carriers was significant (P = .02). The odds ratio for a breast cancer diagnosis was 5.8 in the presence of gynecomastia (95% CI, 1.1-31, P < .04) and 0.52 in the absence of gynecomastia (95% CI, 0.2-1.7, P < .3).CONCLUSION:
Gynecomastia may be associated with an increased risk of breast cancer in carriers. Larger studies are needed to determine whether and when to screen male carriers.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mammography
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Breast Neoplasms, Male
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Early Detection of Cancer
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Gynecomastia
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Mutation
Limits:
Adult
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Aged
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Humans
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Male
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Middle aged
Language:
En
Journal:
Clin Breast Cancer
Journal subject:
NEOPLASIAS
Year:
2024
Document type:
Article
Country of publication: