Investigation of Genetic Association Between a High Activity Variant of Cathepsin G and Risk for Basal Cell Carcinoma.
Anticancer Res
; 44(5): 2091-2094, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38677729
ABSTRACT
BACKGROUND/AIM:
Cathepsin G (CTSG) has been identified as an inhibitor of breast, bladder, and colorectal cancers. The G allele of the N125S (A/G, rs45567233) functional polymorphism of the CTSG gene confers increased serum CTSG activity and has been associated with cardiovascular and neurovascular diseases. This study examined the possible correlation between the pathogenesis of basal cell carcinoma (BCC) and the functional polymorphism CTSG N125S. PATIENTS ANDMETHODS:
A total of 197 DNA samples were examined, comprising 98 BCC patients and 99 control samples of Greek origin. The CTSG N125S polymorphism was molecularly genotyped using PCR amplification, followed by enzyme digestion, and agarose gel electrophoresis of the amplified DNA fragments.RESULTS:
There was no statistically significant difference in the genotypic and allelic frequencies between the patient and the control groups.CONCLUSION:
There is no association between the CTSG N125S polymorphism and pathogenesis of BCC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Basal Cell
/
Genetic Predisposition to Disease
/
Cathepsin G
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Anticancer Res
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: