The beneficial roles and mechanisms of estrogens in immune health and infection disease.
Steroids
; 207: 109426, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38685461
ABSTRACT
Multiple epidemiologic studies have revealed that gender is considered one of the important factors in the frequency and severity of certain infectious diseases, in which estrogens may play a vital role. There is growing evidence that estrogens as female sex hormone can modulate multiple biological functions outside of the reproductive system, such as in brain and cardiovascular system. However, it is largely unknown about the roles and mechanisms of estrogens/estrogen receptors in immune health and infection disease. Thence, by reading a lot of literature, we summarized the regulatory mechanisms of estrogens/estrogen receptors in immune cells and their roles in certain infectious diseases with gender differences. Therefore, estrogens may have therapeutic potentials to prevent and treat these infectious diseases, which needs further clinical investigation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Estrogens
Limits:
Animals
/
Humans
Language:
En
Journal:
Steroids
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: