Oleanane and 30-noroleanane triterpenoids from the roots of Paeonia lactiflora.
Fitoterapia
; 176: 105981, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38685513
ABSTRACT
An investigation of EtOAc extract from the roots of Paeonia lactiflora yielded three new 30-noroleanane triterpenoids paeonenoides L-N (1-3) and one new oleanane triterpenoid paeonenoide O (4) together with 7 known compounds (5-11). Extensive spectrographic experiments were applied to identify the structures of 1-4, and their absolute configurations were unambiguously determined by theoretical calculations of ECD spectra, as well as the single-crystal X-ray diffraction analysis. Compounds 8, 9 and 10 were isolated from the Paeonia genus for the first time. Moreover, compounds 8, 9 and 11 showed inhibitory activities against LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with the IC50 values of 72. 17 ± 4.74, 30.02 ± 2.03 and 28.34 ± 1.85 µM, respectively.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oleanolic Acid
/
Plant Roots
/
Paeonia
/
Phytochemicals
/
Nitric Oxide
Limits:
Animals
Country/Region as subject:
Asia
Language:
En
Journal:
Fitoterapia
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: