Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors.
J Cancer Res Clin Oncol
; 150(5): 221, 2024 Apr 30.
Article
in En
| MEDLINE
| ID: mdl-38687357
ABSTRACT
Vascular endothelial growth factor A (VEGF-A), a highly conserved dimeric glycoprotein, is a key regulatory gene and a marker molecule of angiogenesis. The upregulation of VEGF-A facilitates the process of tumor vascularization, thereby fostering the initiation and progression of malignant neoplasms. Many genes can adjust the angiogenesis of tumors by changing the expression of VEGF-A. In addition, VEGF-A also exhibits immune regulatory properties, which directly or indirectly suppresses the antitumor activity of immune cells. The emergence of VEGF-A-targeted therapy alone or in rational combinations has revolutionized the treatment of various cancers. This review discusses how diverse mechanisms in various tumors regulate VEGF-A expression to promote tumor angiogenesis and the role of VEGF-A in tumor immune microenvironment. The application of drugs targeting VEGF-A in tumor therapy is also summarized including antibody molecule drugs and traditional Chinese medicine.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vascular Endothelial Growth Factor A
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Molecular Targeted Therapy
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Tumor Microenvironment
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Neoplasms
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Neovascularization, Pathologic
Limits:
Animals
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Humans
Language:
En
Journal:
J Cancer Res Clin Oncol
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: