The rates of septicemia in older adults with prostate cancer treated with abiraterone or enzalutamide: A population-based study.
J Geriatr Oncol
; 15(5): 101773, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38703693
ABSTRACT
INTRODUCTION:
Prostate cancer (PCa) is the most common non-cutaneous tumor among American men. Androgen receptor signaling inhibitors such as abiraterone and enzalutamide have been approved for similar disease states among patients with advanced PCa. Existing data suggest using steroids is associated with an increased risk of infection. Because abiraterone is usually prescribed with prednisone, we sought to compare the risk of septicemia in patients using abiraterone vs. enzalutamide. MATERIALS ANDMETHODS:
We utilized the SEER-Medicare-linked data and used negative binomial regression models to compare the changes in the rates of septicemia-related hospitalizations six months pre- and post-abiraterone and enzalutamide initiation.RESULTS:
We found that the incidence of septicemia-related hospitalizations increased 2.77 fold within six months of initiating abiraterone (incidence rate ratio [IRR] 2.77, 95% confidence interval [CI] 2.17-3.53) 1.97 fold within six months of starting enzalutamide (IRR 1.97, 95% CI 1.43-2.72). However, the difference in the changes did not reach statistical significance (interaction IRR 0.71, 95% CI 0.48-1.06).DISCUSSION:
The findings suggest that both abiraterone and enzalutamide are associated with an increased risk of septicemia-related hospitalizations. However, the difference in the increase of septicemia risk following the two treatments did not reach statistical significance. Further studies are warranted to understand the mechanisms at play.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylthiohydantoin
/
Benzamides
/
Sepsis
/
Androstenes
/
Nitriles
Limits:
Aged
/
Aged80
/
Humans
/
Male
Country/Region as subject:
America do norte
Language:
En
Journal:
J Geriatr Oncol
Year:
2024
Document type:
Article