Metabolic liability for weight gain in early adulthood.
Cell Rep Med
; 5(5): 101548, 2024 May 21.
Article
in En
| MEDLINE
| ID: mdl-38703763
ABSTRACT
While weight gain is associated with a host of chronic illnesses, efforts in obesity have relied on single "snapshots" of body mass index (BMI) to guide genetic and molecular discovery. Here, we study >2,000 young adults with metabolomics and proteomics to identify a metabolic liability to weight gain in early adulthood. Using longitudinal regression and penalized regression, we identify a metabolic signature for weight liability, associated with a 2.6% (2.0%-3.2%, p = 7.5 × 10-19) gain in BMI over ≈20 years per SD higher score, after comprehensive adjustment. Identified molecules specified mechanisms of weight gain, including hunger and appetite regulation, energy expenditure, gut microbial metabolism, and host interaction with external exposure. Integration of longitudinal and concurrent measures in regression with Mendelian randomization highlights the complexity of metabolic regulation of weight gain, suggesting caution in interpretation of epidemiologic or genetic effect estimates traditionally used in metabolic research.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Weight Gain
/
Body Mass Index
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Cell Rep Med
Year:
2024
Document type:
Article
Country of publication: