The Menin story in acute myeloid leukaemia-The road to success.
Br J Haematol
; 205(3): 812-814, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38710595
ABSTRACT
The treatment of acute myeloid leukaemia (AML) has changed fundamentally in the last decade with many new targeted therapies entering clinics. Some of the most interesting agents under development are Menin inhibitors which interfere with the interaction of Menin with wild-type (wt) KMT2A or a KMT2A-fusion protein and thereby downregulate the leukaemic gene expression (MEIS1, PBX3, HOX) in NPM1 mutant or KMT2A-rearranged leukaemia. Other HOX and MEIS1 expressing leukaemias may also be sensitive to Menin inhibition. Following the encouraging results as monotherapy in refractory and relapsed AML, the combination of Menin inhibitors with chemotherapeutic agents and other targeted drugs is being investigated clinically.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, Myeloid, Acute
/
Proto-Oncogene Proteins
/
Nucleophosmin
Limits:
Humans
Language:
En
Journal:
Br J Haematol
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: