A short guide to the tight junction.
J Cell Sci
; 137(9)2024 05 01.
Article
in En
| MEDLINE
| ID: mdl-38712627
ABSTRACT
Tight junctions (TJs) are specialized regions of contact between cells of epithelial and endothelial tissues that form selective semipermeable paracellular barriers that establish and maintain body compartments with different fluid compositions. As such, the formation of TJs represents a critical step in metazoan evolution, allowing the formation of multicompartmental organisms and true, barrier-forming epithelia and endothelia. In the six decades that have passed since the first observations of TJs by transmission electron microscopy, much progress has been made in understanding the structure, function, molecular composition and regulation of TJs. The goal of this Perspective is to highlight the key concepts that have emerged through this research and the future challenges that lie ahead for the field.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tight Junctions
Limits:
Animals
/
Humans
Language:
En
Journal:
J Cell Sci
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: