Your browser doesn't support javascript.
loading
A comprehensive genetic map of cytokine responses in Lyme borreliosis.
Botey-Bataller, Javier; Vrijmoeth, Hedwig D; Ursinus, Jeanine; Kullberg, Bart-Jan; van den Wijngaard, Cees C; Ter Hofstede, Hadewych; Alaswad, Ahmed; Gupta, Manoj K; Roesner, Lennart M; Huehn, Jochen; Werfel, Thomas; Schulz, Thomas F; Xu, Cheng-Jian; Netea, Mihai G; Hovius, Joppe W; Joosten, Leo A B; Li, Yang.
Affiliation
  • Botey-Bataller J; Department of Internal Medicine and Radboudumc Community for Infectious Diseases, Radboud university medical center, Nijmegen, the Netherlands.
  • Vrijmoeth HD; Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Ursinus J; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Kullberg BJ; Department of Internal Medicine and Radboudumc Community for Infectious Diseases, Radboud university medical center, Nijmegen, the Netherlands.
  • van den Wijngaard CC; National Institute for Public Health and Environment (RIVM), Center for Infectious Disease Control, Bilthoven, the Netherlands.
  • Ter Hofstede H; National Institute for Public Health and Environment (RIVM), Center for Infectious Disease Control, Bilthoven, the Netherlands.
  • Alaswad A; Department of Internal Medicine, Division of Infectious Diseases & Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
  • Gupta MK; Department of Internal Medicine and Radboudumc Community for Infectious Diseases, Radboud university medical center, Nijmegen, the Netherlands.
  • Roesner LM; National Institute for Public Health and Environment (RIVM), Center for Infectious Disease Control, Bilthoven, the Netherlands.
  • Huehn J; Department of Internal Medicine and Radboudumc Community for Infectious Diseases, Radboud university medical center, Nijmegen, the Netherlands.
  • Werfel T; Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Schulz TF; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Xu CJ; Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Netea MG; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Hovius JW; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.
  • Joosten LAB; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.
  • Li Y; Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Nat Commun ; 15(1): 3795, 2024 May 07.
Article in En | MEDLINE | ID: mdl-38714679
ABSTRACT
The incidence of Lyme borreliosis has risen, accompanied by persistent symptoms. The innate immune system and related cytokines are crucial in the host response and symptom development. We characterized cytokine production capacity before and after antibiotic treatment in 1,060 Lyme borreliosis patients. We observed a negative correlation between antibody production and IL-10 responses, as well as increased IL-1Ra responses in patients with disseminated disease. Genome-wide mapping the cytokine production allowed us to identify 34 cytokine quantitative trait loci (cQTLs), with 31 novel ones. We pinpointed the causal variant at the TLR1-6-10 locus and validated the regulation of IL-1Ra responses at transcritpome level using an independent cohort. We found that cQTLs contribute to Lyme borreliosis susceptibility and are relevant to other immune-mediated diseases. Our findings improve the understanding of cytokine responses in Lyme borreliosis and provide a genetic map of immune function as an expanded resource.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lyme Disease / Cytokines / Quantitative Trait Loci Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lyme Disease / Cytokines / Quantitative Trait Loci Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: