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Mechanistic insights into cardiovascular effects of ultrafine particle exposure: A longitudinal panel study.
Jiang, Yixuan; Zhu, Xinlei; Shen, Yang; He, Yu; Fan, Hao; Xu, Xueyi; Zhou, Lu; Zhu, Yixiang; Xue, Xiaowei; Zhang, Qingli; Du, Xihao; Zhang, Lina; Zhang, Yang; Liu, Cong; Niu, Yue; Cai, Jing; Kan, Haidong; Chen, Renjie.
Affiliation
  • Jiang Y; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Zhu X; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Shen Y; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • He Y; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Fan H; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Xu X; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Zhou L; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Zhu Y; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Xue X; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Zhang Q; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Du X; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Zhang L; School of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
  • Zhang Y; Department of Systems Biology for Medicine, and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Liu C; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Niu Y; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Cai J; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Kan H; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China; Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China. Electronic address: kanh@fudan.edu.cn.
  • Chen R; Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China; School of Public Health, Hengyang Medical School, University of South China, Hengyang, China. Electronic address: chenrenjie@fudan.edu.cn.
Environ Int ; 187: 108714, 2024 May.
Article in En | MEDLINE | ID: mdl-38718674
ABSTRACT

BACKGROUND:

Ultrafine particle (UFP) has been linked with higher risks of cardiovascular diseases; however, the biological mechanisms remain to be fully elucidated.

OBJECTIVES:

This study aims to investigate the cardiovascular responses to short-term UFP exposure and the biological pathways involved.

METHODS:

A longitudinal panel study was conducted among 32 healthy, non-smoking young adults in Shanghai, China, who were engaged in five rounds of follow-ups between December 2020 and November 2021. Individual exposures were calculated based on the indoor and outdoor real-time measurements. Blood pressure, arterial stiffness, targeted biomarkers, and untargeted proteomics and metabolomics were examined during each follow-up. Linear mixed-effect models were applied to analyze the exposure and health data. The differential proteins and metabolites were used for pathway enrichment analyses.

RESULTS:

Short-term UFP exposure was associated with significant increases in blood pressure and arterial stiffness. For example, systolic blood pressure increased by 2.10 % (95 % confidence interval 0.63 %, 3.59 %) corresponding to each interquartile increase in UFP concentrations at lag 0-3 h, while pulse wave velocity increased by 2.26 % (95 % confidence interval 0.52 %, 4.04 %) at lag 7-12 h. In addition, dozens of molecular biomarkers altered significantly. These effects were generally present within 24 h after UFP exposure, and were robust to the adjustment of co-pollutants. Molecular changes detected in proteomics and metabolomics analyses were mainly involved in systemic inflammation, oxidative stress, endothelial dysfunction, coagulation, and disturbance in lipid transport and metabolism.

DISCUSSION:

This study provides novel and compelling evidence on the detrimental subclinical cardiovascular effects in response to short-term UFP exposure. The multi-omics profiling further offers holistic insights into the underlying biological pathways.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Air Pollutants / Particulate Matter Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Environ Int Year: 2024 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Air Pollutants / Particulate Matter Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Environ Int Year: 2024 Document type: Article Affiliation country: