The compelling role of allopurinol in hyperuricemia-induced epilepsy: Unrecognized like tears in rain.
Brain Res Bull
; 213: 110973, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38723694
ABSTRACT
Epilepsy is a common neurological disease characterized by the recurrent, paroxysmal, and unprovoked seizures. It has been shown that hyperuricemia enhances and associated with the development and progression of epilepsy through induction of inflammation and oxidative stress. In addition, uric acid is released within the brain and contributes in the development of neuronal hyperexcitability and epileptic seizure. Brain uric acid acts as damage associated molecular pattern (DAMP) activates the immune response and induce the development of neuroinflammation. Therefore, inhibition of xanthine oxidase by allopurinol may reduce hyperuricemia-induced epileptic seizure and associated oxidative stress and inflammation. However, the underlying mechanism of allopurinol in the epilepsy was not fully elucidated. Therefore, this review aims to revise from published articles the link between hyperuricemia and epilepsy, and how allopurinol inhibits the development of epileptic seizure.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Allopurinol
/
Hyperuricemia
/
Epilepsy
Limits:
Animals
/
Humans
Language:
En
Journal:
Brain Res Bull
Year:
2024
Document type:
Article