Social Environment, Lifestyle, and Genetic Predisposition With Dementia Risk: A Long-Term Longitudinal Study Among Older Adults.
J Gerontol A Biol Sci Med Sci
; 79(7)2024 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-38733088
ABSTRACT
BACKGROUND:
The role of social environment, that is, the aggregate effect of social determinants of health (SDOHs), in determining dementia is unclear.METHODS:
We developed a novel polysocial risk score for dementia based on 19 SDOH among 5 199 participants in the Health and Retirement Study, United States, to measure the social environmental risk. We used a survival analysis approach to assess the association between social environment and dementia risk in 2006-2020. We further studied the interaction between social environment and lifestyles, and explored racial disparities.RESULTS:
The study participants (mean ageâ =â 73.4 years, SDâ =â 8.3; 58.0% female; 11.6% African American) were followed up for an average of 6.2 years, and 1 089 participants developed dementia. Every 1-point increase in the polysocial risk score (ranging from 0 to 10) was associated with a 21.6% higher risk (adjusted hazard ratio [aHR]â =â 1.21, 95% confidence intervals [95% CI]â =â 1.15-1.26) of developing dementia, other things being equal. Among participants with high social environmental risk, regular exercise and moderate drinking were associated with a 43%-60% lower risk of developing dementia (pâ <â .001). In addition, African Americans were 1.3 times (aHRâ =â 2.28, 95% CIâ =â 1.96-2.66) more likely to develop dementia than European Americans, other things being equal.CONCLUSION:
An adverse social environment is linked to higher dementia risk, but healthy lifestyles can partially offset the increased social environmental risk. The polysocial risk score can complement the existing risk tools to identify high-risk older populations, and guide the design of targeted social environmental interventions, particularly focusing on improving the companionship of the older people, to prevent dementia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Social Environment
/
Genetic Predisposition to Disease
/
Dementia
/
Social Determinants of Health
/
Life Style
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
America do norte
Language:
En
Journal:
J Gerontol A Biol Sci Med Sci
Journal subject:
GERIATRIA
Year:
2024
Document type:
Article
Affiliation country: