Association of depressive symptoms with incident fractures: the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT).
Osteoporos Int
; 35(7): 1261-1271, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38733393
ABSTRACT
This 5-year longitudinal study investigated the relationship between depressive symptoms and fracture risk in a large Japanese cohort. Depressive symptoms were a significant risk factor for hip fractures in women. PURPOSE:
A relationship between depressive symptoms and fractures has not been clearly demonstrated. We aimed to investigate the relationship between depressive symptoms and 5-year fracture risk in the Japan Public Health Center-based Prospective Study for the Next Generation.METHODS:
From 2011 to 2016, 114,092 participants were enrolled, and a follow-up survey was conducted 5 years later. We analyzed 30,552 men and 38,063 women aged 40-74 years who had no past fractures at baseline. Presence of depressive symptoms was defined as a modified 11-item Center for Epidemiological Studies Depression Scale score of 8 or higher, a history of depression, or use of antidepressants. Subjects were asked to report vertebral, upper limb, and/or hip fractures, except for traffic or work accidents, that occurred during the follow-up period. The adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for fracture were analyzed via logistic regression analysis to evaluate the relationship between depressive symptoms and fracture.RESULTS:
Women with depressive symptoms demonstrated a high AOR for hip fractures (AOR 2.78, 95% CI 1.30 - 5.92); this result was consistent in post menopause women. In men, this association was not found for any age group or any type of fracture.CONCLUSIONS:
Depressive symptoms in women may increase the risk of hip fractures. Further studies are required to explore this relationship in more detail.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Depression
/
Osteoporotic Fractures
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Osteoporos Int
Journal subject:
METABOLISMO
/
ORTOPEDIA
Year:
2024
Document type:
Article
Affiliation country: