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The response of pancreatic acinar cell carcinoma to platinum and olaparib therapy in a germline BRCA2 variant carrier: case report and literature review.
Matsubayashi, Hiroyuki; Todaka, Akiko; Tsushima, Takahiro; Kiyozumi, Yoshimi; Harada, Rina; Ishihara, Eiko; Higashigawa, Satomi; Ohike, Nobuyuki; Sakamoto, Hiroki; Sato, Junya; Ishiwatari, Hirotoshi; Sugiura, Teichi; Uesaka, Katsuhiko.
Affiliation
  • Matsubayashi H; Division of Genetic Medicine Promotion, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan. h.matsubayashi@scchr.jp.
  • Todaka A; Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan. h.matsubayashi@scchr.jp.
  • Tsushima T; Division of Medical Oncology and Hematology, Faculty of Medicine, Oita University, Oita, Japan.
  • Kiyozumi Y; Division of GI Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
  • Harada R; Division of Genetic Medicine Promotion, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
  • Ishihara E; Division of Genetic Medicine Promotion, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
  • Higashigawa S; Division of Genetic Medicine Promotion, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
  • Ohike N; Division of Genetic Medicine Promotion, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
  • Sakamoto H; Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.
  • Sato J; Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
  • Ishiwatari H; Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
  • Sugiura T; Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
  • Uesaka K; Hepato-Biliary-Pancreatic Surgery of Shizuoka Cancer Center, Shizuoka, Japan.
Fam Cancer ; 23(3): 393-398, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38733420
ABSTRACT
A 73-year-old Japanese man with a history of distal biliary cancer treated by pancreatoduodenectomy developed pancreatic acinar cell carcinoma (PACC) treated by remnant pancreatectomy and adjuvant chemotherapy. Thirteen months after surgery, multiple liver metastases developed and FOLFOX chemotherapy was initiated. Based on the PACC diagnosis and a positive family history for breast and ovarian cancer genetic testing was performed which revealed a pathogenic germline BRCA2 variant (c.8629G > T, p.Glu2877Ter). Olaparib therapy was initiated and the metastases responded well (partial response). PACC is a BRCA2-associated cancer which may respond well to PARP inhibitors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Phthalazines / Piperazines / Antineoplastic Combined Chemotherapy Protocols / Germ-Line Mutation / Carcinoma, Acinar Cell / BRCA2 Protein Limits: Aged / Humans / Male Language: En Journal: Fam Cancer Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Phthalazines / Piperazines / Antineoplastic Combined Chemotherapy Protocols / Germ-Line Mutation / Carcinoma, Acinar Cell / BRCA2 Protein Limits: Aged / Humans / Male Language: En Journal: Fam Cancer Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Country of publication: