B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles.
Commun Biol
; 7(1): 584, 2024 May 16.
Article
in En
| MEDLINE
| ID: mdl-38755239
ABSTRACT
B cells are important in tuberculosis (TB) immunity, but their role in the human lung is understudied. Here, we characterize B cells from lung tissue and matched blood of patients with TB and found they are decreased in the blood and increased in the lungs, consistent with recruitment to infected tissue, where they are located in granuloma associated lymphoid tissue. Flow cytometry and transcriptomics identify multiple B cell populations in the lung, including those associated with tissue resident memory, germinal centers, antibody secretion, proinflammatory atypical B cells, and regulatory B cells, some of which are expanded in TB disease. Additionally, TB lungs contain high levels of Mtb-reactive antibodies, specifically IgM, which promotes Mtb phagocytosis. Overall, these data reveal the presence of functionally diverse B cell subsets in the lungs of patients with TB and suggest several potential localized roles that may represent a target for interventions to promote immunity or mitigate immunopathology.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
B-Lymphocytes
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Commun Biol
/
Commun. biolog
/
Communications biology
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: