Symptomatic progression of frontotemporal dementia with the TARDBP I383V variant.
Neurocase
; 30(1): 39-47, 2024 02.
Article
in En
| MEDLINE
| ID: mdl-38757415
ABSTRACT
We present a longitudinal description of a man with the TARDBP I383V variant of frontotemporal dementia (FTD). His progressive changes in behavior and language resulted in a diagnosis of the right temporal variant of FTD, also called the semantic behavioral variant (sbvFTD). We also present data from a small series of patients with the TARDBP I383V variant who were enrolled in a nationwide FTD research collaboration (ALLFTD). These data support slowly progressive loss of semantic function. While semantic dementia is infrequently considered genetic, the TARDBP I383V variant seems to be an exception. Longitudinal analyses in larger samples are warranted.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Disease Progression
/
DNA-Binding Proteins
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Frontotemporal Dementia
Limits:
Humans
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Male
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Middle aged
Language:
En
Journal:
Neurocase
Journal subject:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
/
PSICOLOGIA
/
PSIQUIATRIA
Year:
2024
Document type:
Article
Affiliation country: