Fibrinogen: Structure, abnormalities and laboratory assays.
Adv Clin Chem
; 120: 117-143, 2024.
Article
in En
| MEDLINE
| ID: mdl-38762239
ABSTRACT
Fibrinogen is the primary precursor protein for the fibrin clot, which is the final target of blood clotting. It is also an acute phase reactant that can vary under physiologic and inflammatory conditions. Disorders in fibrinogen concentration and/or function have been variably linked to the risk of bleeding and/or thrombosis. Fibrinogen assays are commonly used in the management of bleeding as well as the treatment of thrombosis. This chapter examines the structure of fibrinogen, its role in hemostasis as well as in bleeding abnormalities and measurement thereof with respect to clinical management.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fibrinogen
Limits:
Humans
Language:
En
Journal:
Adv Clin Chem
Year:
2024
Document type:
Article
Country of publication: