Region-specific and age-related differences in astrocytes in the human brain.
Neurobiol Aging
; 140: 102-115, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38763075
ABSTRACT
Astrocyte heterogeneity and its relation to aging in the normal human brain remain poorly understood. We here analyzed astrocytes in gray and white matter brain tissues obtained from donors ranging in age between the neonatal period to over 100 years. We show that astrocytes are differently distributed with higher density in the white matter. This regional difference in cellular density becomes less prominent with age. Additionally, we confirm the presence of morphologically distinct astrocytes, with gray matter astrocytes being morphologically more complex. Notably, gray matter astrocytes morphologically change with age, while white matter astrocytes remain relatively consistent in morphology. Using regional mass spectrometry-based proteomics, we did, however, identify astrocyte specific proteins with regional differences in abundance, reflecting variation in cellular density or expression level. Importantly, the expression of some astrocyte specific proteins region-dependently decreases with age. Taken together, we provide insights into region- and age-related differences in astrocytes in the human brain.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
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Astrocytes
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Gray Matter
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White Matter
Limits:
Adolescent
/
Adult
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Aged
/
Aged80
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Child
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Child, preschool
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Female
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Humans
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Infant
/
Male
Language:
En
Journal:
Neurobiol Aging
Year:
2024
Document type:
Article
Affiliation country: