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Glechomenes A-G, diterpenoids with anti-inflammatory activities from the aerial part of Glechoma longituba.
Zhang, Qian; Lu, Meilong; Liu, Tianzi; Zheng, Xiuqin; Chen, Tianqi; Yang, Li; Ding, Lili; Yang, Yingbo; Han, Zhuzhen; Gu, Lihua; Wang, Zhengtao.
Affiliation
  • Zhang Q; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China.
  • Lu M; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China.
  • Liu T; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China.
  • Zheng X; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Chen T; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China.
  • Yang L; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China.
  • Ding L; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China.
  • Yang Y; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
  • Han Z; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China. Electronic address: hltang@126.co
  • Gu L; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China. Electronic address: lhgu@shutcm.e
  • Wang Z; The MOE Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai 201203, China. Electronic address: ztwang@shutcm
Fitoterapia ; 176: 106034, 2024 Jul.
Article in En | MEDLINE | ID: mdl-38795853
ABSTRACT
Ten diterpenoids including six unreported abietane-type diterpenoids Glecholmenes A-F (1-6) and an undescribed labdane-type diterpenoid Glecholmene G (9), together with three known diterpenoids (7,8,10), were firstly isolated from the aerial part of G. longituba. Their structures were established mainly by nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) methods. Electronic circular dichroism (ECD) calculations and X-ray crystallographic analyses were used for the determination of their absolute configurations. The anti-inflammatory activity of all compounds was evaluated using the classical LPS-induced NO release model in RAW264.7 cells. Compound 2 displayed significant anti-inflammatory activities with IC50 values of 29.08 ± 1.40 µM (Aminoguanidine hydrochloride as the positive control, IC50 = 21.84 ± 0.48 µM).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Components, Aerial / Diterpenes / Phytochemicals / Anti-Inflammatory Agents Limits: Animals Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Components, Aerial / Diterpenes / Phytochemicals / Anti-Inflammatory Agents Limits: Animals Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2024 Document type: Article Affiliation country: Country of publication: