Mitochondrial quality control in human health and disease.
Mil Med Res
; 11(1): 32, 2024 May 29.
Article
in En
| MEDLINE
| ID: mdl-38812059
ABSTRACT
Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable in vital life processes such as cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, a sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key processes like mitochondrial biogenesis, mitochondrial dynamics, and mitophagy, which have garnered increasing attention from researchers to unveil their specific molecular mechanisms. In this review, we present a comprehensive summary of the primary mechanisms and functions of key regulators involved in major components of MQC. Furthermore, the critical physiological functions regulated by MQC and its diverse roles in the progression of various systemic diseases have been described in detail. We also discuss agonists or antagonists targeting MQC, aiming to explore potential therapeutic and research prospects by enhancing MQC to stabilize mitochondrial function.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mitophagy
/
Mitochondria
Limits:
Humans
Language:
En
Journal:
Mil Med Res
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: