The developmental processes of ventricular septal defects with outflow tract malalignment.
Ann Anat
; 255: 152293, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38823492
ABSTRACT
Ventricular septal defects (VSD) with outflow tract (OFT) malalignment are a common group of congenital heart diseases with varying severity. The developmental process of these defects is challenging to understand due to the complex nature of cardiac morphogenesis and the difficulties in visualizing the temporal and spatial changes that occur during pathogenesis. However, recent advancements in imaging techniques, such as high-resolution episcopic microscopy, have provided valuable insights into the normal septation of ventricular chambers and OFT alignment. Building upon this knowledge, we have utilized lightsheet microscopy, another innovative imaging method, to further investigate the developmental processes that lead to abnormal formation of the ventricular septum and the malalignment of arterial roots with the ventricular chambers. Our study highlights endocardial cushion hypoplasia and insufficient rotation of the outflow tract as two interrelated central factors contributing to the pathogenesis of these defects. This finding has the potential to enhance our understanding of the etiology of congenital heart diseases and may contribute to the development of improved diagnostic and therapeutic strategies in the future.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heart Septal Defects, Ventricular
Limits:
Animals
/
Humans
Language:
En
Journal:
Ann Anat
/
Ann. anat
/
Annals of anatomy
Journal subject:
ANATOMIA
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: