Micronutrient (iron, selenium, vitamin D) supplementation and the gut microbiome.
Curr Opin Clin Nutr Metab Care
; 27(5): 421-427, 2024 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-38836886
ABSTRACT
PURPOSE OF REVIEW Deficiencies in micronutrients persist as widespread global challenges, where supplementation remains a crucial therapeutic approach. This review aims to elucidate the intricate relationships between micronutrient supplementation - specifically iron, selenium (Se), and vitamin D (Vit D) - and gut microbiota composition, investigating their collective impact on host health and disease susceptibility. RECENT FINDINGS:
Maintaining balanced iron levels is essential for gut microbiota equilibrium and host health, as both iron deficiency and excess disrupt gut bacterial balance, affecting colon health. Se supplementation can restore and improve the gut microbial balance, influencing health outcomes not only in the gut but also in areas such as neuroprotection in the brain, testicular health, and metabolic syndrome. Clinical and experimental models demonstrate that Vit D modulates the gut microbiome, enhancing anti-inflammatory effects, supporting metabolic health, and potentially reducing the risk of gut-related behavioral changes and diseases.SUMMARY:
Findings of this review emphasize that balanced iron levels are essential for maintaining a healthy gut microbiota composition and underscore the beneficial effects of Se and Vit D in modulating the gut microbiome. The interactions between micronutrients and the gut microbiome are complex but may have a broad spectrum of health outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Selenium
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Vitamin D
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Micronutrients
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Dietary Supplements
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Gastrointestinal Microbiome
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Iron
Limits:
Animals
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Humans
Language:
En
Journal:
Curr Opin Clin Nutr Metab Care
Journal subject:
CIENCIAS DA NUTRICAO
/
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: