Epigenetic predictors of species maximum life span and other life-history traits in mammals.
Sci Adv
; 10(23): eadm7273, 2024 Jun 07.
Article
in En
| MEDLINE
| ID: mdl-38848365
ABSTRACT
By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation (DNAm) predictors of maximum life span (R = 0.89), gestation time (R = 0.96), and age at sexual maturity (R = 0.85). Our maximum life-span predictor indicates a potential innate longevity advantage for females over males in 17 mammalian species including humans. The DNAm maximum life-span predictions are not affected by caloric restriction or partial reprogramming. Genetic disruptions in the somatotropic axis such as growth hormone receptors have an impact on DNAm maximum life span only in select tissues. Cancer mortality rates show no correlation with our epigenetic estimates of life-history traits. The DNAm maximum life-span predictor does not detect variation in life span between individuals of the same species, such as between the breeds of dogs. Maximum life span is determined in part by an epigenetic signature that is an intrinsic species property and is distinct from the signatures that relate to individual mortality risk.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA Methylation
/
Epigenesis, Genetic
/
Longevity
/
Mammals
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Sci Adv
Year:
2024
Document type:
Article
Affiliation country: