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Effect of lixisenatide on liquid gastric emptying in type 2 diabetes - Implications for the use of GLP-1 receptor agonists before procedures.
Kovoor, Joshua G; Rayner, Christopher K; Wu, Tongzhi; Jalleh, Ryan J; Maddern, Guy J; Horowitz, Michael; Jones, Karen L.
Affiliation
  • Kovoor JG; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia; The University of Adelaide, Discipline of Surgery, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
  • Rayner CK; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia; Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  • Wu T; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia; Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  • Jalleh RJ; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia; Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  • Maddern GJ; The University of Adelaide, Discipline of Surgery, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
  • Horowitz M; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia; Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  • Jones KL; Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia; Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia. Electronic address: karen.jones@adelaide.edu.au.
J Diabetes Complications ; 38(8): 108793, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38870730
ABSTRACT
Gastric emptying of a glucose drink was measured in people with type 2 diabetes given lixisenatide (20 µg/day or placebo) for 8 weeks. Intragastric retention at 240 min (2 (0-11)% vs 48 (3-97)%; P < 0.0001) was much greater with lixisenatide than placebo. Accordingly, lixisenatide may delay liquid gastric emptying markedly.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Diabetes Mellitus, Type 2 / Gastric Emptying / Glucagon-Like Peptide-1 Receptor Agonists / Hypoglycemic Agents Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Diabetes Complications Journal subject: ENDOCRINOLOGIA Year: 2024 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Diabetes Mellitus, Type 2 / Gastric Emptying / Glucagon-Like Peptide-1 Receptor Agonists / Hypoglycemic Agents Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Diabetes Complications Journal subject: ENDOCRINOLOGIA Year: 2024 Document type: Article Affiliation country: