Anti-T-lymphocyte globulin (ATLG) compared to post-transplant cyclophosphamide as GvHD prophylaxis in ALL patients undergoing allogeneic stem cell transplantation.
Bone Marrow Transplant
; 59(9): 1265-1274, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38877098
ABSTRACT
We retrospectively analyzed high-risk ALL patients in CR1 receiving total body irradiation based conditioning regimen with ATLG (n = 74) or PTCy (n = 73) for GVHD prophylaxis. The 3-year OS and LFS were similar in both groups 65 and 60% in the ATLG group and 64 and 67% in the PTCy group (p = 0.9 and 0.5, respectively). CIR and NRM rate at three years was 12 and 21% after PTCy and 19 and 20% after ATLG (p = 0.4 and p = 0.9, respectively). Acute GvHD grades II-IV and grades III/IV at 100 days was 46 and 19% after PTCy and 33 and 10% after ATLG (p = 0.08 and p = 0.9, respectively). Chronic GvHD of all grade at two years was higher after PTCy 55% versus 26% (p < 0.001). Based on the propensity score matching (PSM) analysis, aGvHD grades II-IV was trending higher in the PTCy group compared to the ATLG group (p = 0.07). In contrast to the PSM analysis, on multivariate analysis the receipt of PTCy compared with ATLG was associated with a reduced CIR (p = 0.026). Our retrospective single-center analysis shows a lower incidence of acute and chronic GvHD while displaying similar LFS and OS after ATLG compared to PTCy in TBI based allogeneic stem cell transplantation for high-risk ALL.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cyclophosphamide
/
Graft vs Host Disease
/
Antilymphocyte Serum
Limits:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Bone Marrow Transplant
/
Bone marrow transplant
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Bone marrow transplantation
Journal subject:
TRANSPLANTE
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: