Functional connectivity of the posterior cingulate cortex in autism spectrum disorder.
Psychiatry Res Neuroimaging
; 342: 111848, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38896910
ABSTRACT
The purpose of this study was to assess the functional connectivity of the posterior cingulate cortex in autism spectrum disorder (ASD). We used resting-state functional magnetic resonance imaging (rsfMRI) brain scans of adolescents diagnosed with ASD and a neurotypical control group. The Autism Brain Imaging Data Exchange (ABIDE) consortium was utilized to acquire data from the University of Michigan (145 subjects) and data from the New York University (183 subjects). The posterior cingulate cortex showed reduced connectivity with the anterior cingulate cortex for the ASD group compared to the control group. These two brain regions have previously both been linked to ASD symptomology. Specifically, the posterior cingulate cortex has been associated with behavioral control and executive functions, which appear to be responsible for the repetitive and restricted behaviors (RRB) in ASD. Our findings support previous data indicating a neurobiological basis of the disorder, and the specific functional connectivity changes involving the posterior cingulate cortex and anterior cingulate cortex may be a potential neurobiological biomarker for the observed RRBs in ASD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Magnetic Resonance Imaging
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Autism Spectrum Disorder
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Gyrus Cinguli
Limits:
Adolescent
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Child
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Female
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Humans
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Male
Language:
En
Journal:
Psychiatry Res Neuroimaging
Year:
2024
Document type:
Article
Country of publication: