The why and how of the SynNerGe criteria of Parkinson´s disease.
J Neural Transm (Vienna)
; 131(10): 1149-1154, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-38916622
ABSTRACT
In pursuit of early therapeutic interventions for Parkinson's disease, the proposed SynNeurGe classification system integrates α-synuclein pathology (S), neurodegeneration evidence (N), and pathogenic gene variants (G). This approach aims to address the disease's complexity and biological diversity. It suggests categorizing patients based on the presence or absence of α-synuclein pathology in tissues or cerebrospinal fluid, neurodegeneration indicators from specific imaging techniques, and identification of pathogenic gene variants associated with Parkinson's disease. The proposed system emphasizes the future need for precision medicine and aims to facilitate both basic and clinical research toward disease-modifying therapies. However, the authors stress that initial implementation should be confined to research settings, considering ethical implications and current limitations. Prospective validation of these criteria is deemed necessary to ensure their efficacy and ethical application in clinical practice.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
Limits:
Humans
Language:
En
Journal:
J Neural Transm (Vienna)
Year:
2024
Document type:
Article
Affiliation country:
Country of publication: