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Cerebrospinal fluid distribution and pharmacokinetics of ponatinib in Ph1+ acute lymphoblastic leukemia.
Walczak, Pierre; Fodil, Sofiane; Vignal, Nicolas; Cabannes-Hamy, Aurélie; Boissel, Nicolas; Raffoux, Emmanuel; Cayuela, Jean-Michel; Goldwirt, Lauriane; Lengliné, Etienne.
Affiliation
  • Walczak P; Hematology Department, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Fodil S; Hematology Department, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Vignal N; Université de Paris Cité, Paris, France.
  • Cabannes-Hamy A; Pharmacology Department, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Boissel N; Hematology Department, Centre Hospitalier de Versailles, Versailles, France.
  • Raffoux E; Hematology Department, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Cayuela JM; Université de Paris Cité, Paris, France.
  • Goldwirt L; Hematology Department, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
  • Lengliné E; Université de Paris Cité, Paris, France.
Blood ; 144(10): 1127-1130, 2024 Sep 05.
Article in En | MEDLINE | ID: mdl-38917352
ABSTRACT
ABSTRACT Tyrosine kinase inhibitors efficacy in central nervous system (CNS) disease remains uncertain. Ponatinib was studied for CNS distribution in 16 patients with Philadelphia-positive acute lymphoblastic leukemia. Cerebrospinal fluid concentrations fell below the 40 nM threshold, suggesting suboptimal CNS exposure.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridazines / Protein Kinase Inhibitors / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Imidazoles Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Blood Year: 2024 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridazines / Protein Kinase Inhibitors / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Imidazoles Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Blood Year: 2024 Document type: Article Affiliation country: Country of publication: